Endocrine Abstracts

Resistin is a recently discovered 12.5 kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes and plays important role in the development of insulin resistance and obesity. Recently, many investigators have linked resistin to reproductive function. Resistin expression was observed in bovine and rat ovaries and showed that resistin modulate granulosa cells function such as steroidogenesis and proliferation, in basal state or in response to IGF-I in vit...

Resistin, a new 12.5 kDa cysteine-rich protein, which is specifically secreted by adipocytes and describe as a potential link between obesity and insulin resistance. Recently, resistin and PPARs receptors was found in reproductive tissue such as ovary and it was found that resistin modulate ovarian follicle function. Additionally, thiazolidinediones, such as rosiglitazone, a synthetic agonist of PPAR-γ down-regulated resistin expression in rodents. The aim of the study wa...

Introduction: Adolescents with type 1 diabetes often have poor control causing them significant future danger. An area of particular concern is that of worsening control around the complex time of transition to young adult services from paediatric services. Multiple guidelines and methods to help better this control and transition process are in place.Aim: This study aims to survey attitudes towards and possible improvements to clinics to aid adherence a...

Primary hyperparathyroidism (PHPT) is a common reason for referral to the endocrinology team. We aimed to estimate the prevalence of associated vitamin D deficiency and osteoporosis, to evaluate the usefulness of imaging studies in identifying a parathyroid adenoma prior to surgery and to assess response to surgical treatment in the setting of a District General Hospital.We searched our outpatient clinic letters and identified 64 patients diagnosed with ...

After suffering three spontaneous pneumothoraces, Mr A was due to have definitive treatment in the form of video-assisted thoracoscopy and pleurodesis. Soon after ‘induction of anaesthesia’ he developed severe hypertension; 130/80 →300/220 associated with global high take off and ST elevation on the ECG. Labetol was given i.v. after which the blood pressure became unrecordable and an EMD cardiac arrest ensued. Three cycles of cardiac massage and two boluses of ...

Background: Effective management of adrenal insufficiency (AI) during sick day episodes requires adjusting oral glucocorticoid therapy or administering intramuscular injections to prevent adrenal crises. Given the critical nature of adrenal crisis management, educating families of young individuals with AI is essential.Aim: To critically appraise patient education concerning adrenal crisis management through a systematic...

Background: Effective management of adrenal insufficiency (AI) during sick day episodes involves adjusting oral glucocorticoid therapy or administering intramuscular injections to prevent adrenal crises. Therefore, educating families of young individuals with AI on emergency management is crucial.Aim: This study aims to critically evaluate online educational materials related to adrenal crisis management. We conducted a ...

Purpose: The pathogenesis of idiopathic GH deficiency (GHD) in children, including possible cerebral metabolic alterations, remains unclear. The aim of the study was to evaluate the metabolic changes within the normal appearing brain in children with GHD using MR spectroscopy (MRS) and to correlate MRS measurements with hormonal concentrations.Materials and methods: 71 children with GHD (mean age 6.9 years) and 11 healthy controls (mean age 8.4 years) we...

It is suggested that radioiodine therapy in hyperthyroidism can increase mortality because of cardiovascular diseases. To determine that fact we have evaluated how the levels of predictors of the cardiovascular risk in serum such as: glucose, insulin, total cholesterol and high-density cholesterol, low-density cholesterol and triglycerides as well as CRP, fibrinogen and D-dimers changed in hyperthyroidism cases before and 12 up to 16 and 24 up to 28 weeks after radioiodine the...

Introduction: It’s known that type 2 diabetes is an independent risk factor for cardiovascular disease. Osteoprotegerin (OPG), a glycoprotein secreted mainly by osteoblasts, is also produced by heart muscle and vessels. Its role in the pathogenesis of atherosclerosis and future cardiovascular events is still discussed.Material and methods: The study was conducted in 113 patients (48 F, 65 M) with type 2 diabetes mellitus (DM2) and coronary heart dis...